Autora de la “Teoría del “Modelo de Peligro” o del Reconocimiento del Sistema Inmunitario ().
El sistema inmunitario no ha evolucionado para discernir entre lo propio y lo extraño, como proponían las bases iniciales de la Inmunología, sino para responder frente a aquello que está causando daño tisular.
Esta teoría explicaba por qué podía aparecer respuesta inmunitaria en ausencia de infección, a la vez que la presencia de algunos microorganismos, como las bacterias del sistema digestivo, no ocasionaba reacción alguna. Según su relato, llegó a ese conocimiento observando las interacciones de su perro pastor con las ovejas de su rebaño.
Nacida en Francia, en , trabajó en el este de los Estados Unidos en múltiples actividades. En uno de sus trabajos, como mesonera en un bar próximo al campus de la Universidad de California, tuvo la oportunidad de contactar con investigadores, y de debatir con ellos. Esto le animó a completar su formación.
Se graduó como bióloga en y realizó su postdoctorado en la Universidad de Cambridge, en Reino Unido. Dirigió durante muchos años una sección del Instituto Nacional de la Salud de los Estados Unidos (NIH).
Soportó durante largo t
Descriptive Transcript
music // Title card reads Back to Basic Toronto, Polly Matzinger PhD. The Danger Model: Update to immune system theory. Polly Matzinger stands alone on the main stage at the Back to Basic conference. An on-screen graphic identifies her as Chief, T-Cell Tolerance and Memory Section Laboratory of Immunogenetics. As she speaks, she draws on an overhead projector.
Polly Matzinger: I’m going to take you through 65 years of immunological theory in one diagram, to show you how we differ from the older models, and how we stand on top of some of them, all right?
Matzinger draws two circles, one labelled &#;B&#; and one labelled &#;Killers.&#;
So, the self-non-self model was invented in by a guy named Macfarlane Burnet in Australia. And, if you look at that model in modern terms, what he said was that the B-cells and the killer cells — the effector arm of the immune system — work by recognizing non-self.
Matzinger draws several arms on the surface of the B-cell circle.
What he said was that a B-cell has on its surface a whole bunch of copies — we now know that it’s about a hundred thousand — of the antibody that it’s going to later make. And, early in li
Notable alumni of
University of California - Irvine
Updated:
EduRank
The University of California - Irvine is th in the world, th in North America, and rd in the United States by aggregated alumni prominence. Below is the list of notable alumni from the University of California - Irvine sorted by their wiki pages popularity. The directory includes famous graduates and former students along with research and academic staff. 3 individuals affiliated with the University of California - Irvine won Nobel Prizes in Physics and Chemistry.
Nazanin Boniadi
- Born in
- Iran
- Years
- (age 45)
- Occupations
- film actoractortelevision actor
- Biography
Nazanin Boniadi is a British actress and activist. Born in Tehran and raised in London, she attended university in the United States, where she landed her first major acting role as Leyla Mir in the soap opera General Hospital (–) and its spin-off General Hospital: Night Shift (). Since then, Boniadi has played Nora in the sitcom How I Met Your Mother (), Fara Sherazi in the spy thriller series Homeland (–), Esther in the historical drama film Ben-Hur (), Clare Quayle in the sci-fi thriller series Counterpart (–), Z
TURNED ON BY DANGER
Turned on by Danger: Programme Notes
Dr Polly Matzinger is a sheep-dog trainer, former bunny girl, and one of the world's foremost immunologists. Four years ago she had a blinding moment of insight that led to a most extraordinary idea, the Danger Model. This film tells the story of how a high school drop out became a scientist, and had an idea that's reshaping the way people think about organ transplants and cancer.
Polly Matzinger left school under the cloud of being voted by her fellow students, "the person least likely to succeed in life". She spent ten years drifting, as a jazz musician, a dog trainer, and then a Playboy bunny. One evening she was serving drinks to a couple of scientists who were discussing their experiments. She asked a few incisive questions. One of the scientists was so impressed that he started a nine-month campaign to persuade her to go back to school to do science. Twenty years later she is chief of an immunology lab at one of America's leading research centres, the National Institutes of Health in Washington, and the main prop
Biographies you may also like
Saint frances xavier cabrini biography books This gripping biography unveils the extraordinary adventures of Mother Cabrini, a visionary Italian American religious sister who defied the odds, founded the Missionary Sisters of the Sacred .
Edan gross biography of abraham lincoln Abraham Lincoln, known for his determination and perseverance, is the most famous U.S. presidents in history. He became the 16 th president of the U.S. on 4th March Missing: edan gross.
Ettore garofalo biography of william hill Ettore Garofolo con Anna Magnani nel film Mamma Roma. Ettore Garofolo, talvolta accreditato come Ettore Garofalo (Roma, 8 marzo – Roma, 24 gennaio ), è stato un attore g: william hill.
Thomas kuhn biography uol external Thomas Kuhn, one of the most influential philosophers of science in the 20th century, revolutionized the way the world perceives and envisions science. His landmark .
Shehla khan designer biography books 18K Followers, 3, Following, Posts - Shehla Khan (@shehlak_) on Instagram: "Designer @shehlaakhan Dreamer and lover of all things beautiful. Love is the greatest thing in the world .
Tevye the dairyman sholem aleichem biography Tevye the Dairyman, penned by Sholom Aleichem, is more than just a collection of tales—it’s a profound exploration of the challenges faced by Eastern European Jews during the early.